{"symbol":"TCF7","synonyms":["TCF-1"],"name":"transcription factor 7 (T-cell specific, HMG-box)","description":"This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]","ncbiEntrezGeneId":6932,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6932","proteins":[{"symbol":"TCF7_HUMAN","href":"/api/1.0/protein/TCF7_HUMAN"}],"hgncRootFamilies":[]}