{"symbol":"TCL1A","synonyms":["TCL1"],"name":"T-cell leukemia/lymphoma 1A","description":"Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]","ncbiEntrezGeneId":8115,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8115","proteins":[{"symbol":"TCL1A_HUMAN","href":"/api/1.0/protein/TCL1A_HUMAN"}],"hgncRootFamilies":[]}