{"symbol":"TDG","synonyms":["HTDG"],"name":"thymine-DNA glycosylase","description":"The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":6996,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6996","proteins":[{"symbol":"TDG_HUMAN","href":"/api/1.0/protein/TDG_HUMAN"}],"hgncRootFamilies":[]}