{"symbol":"TDO2","synonyms":["TO","TPH2","TRPO","HYPTRP"],"name":"tryptophan 2,3-dioxygenase","description":"This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]","ncbiEntrezGeneId":6999,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6999","proteins":[{"symbol":"T23O_HUMAN","href":"/api/1.0/protein/T23O_HUMAN"}],"hgncRootFamilies":[]}