{"symbol":"TDP1","synonyms":[],"name":"tyrosyl-DNA phosphodiesterase 1","description":"The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016]","ncbiEntrezGeneId":55775,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/55775","proteins":[{"symbol":"TYDP1_HUMAN","href":"/api/1.0/protein/TYDP1_HUMAN"}],"hgncRootFamilies":[]}