{"symbol":"TFEC","synonyms":["TCFEC","BHLHE34","TFE-C","TFECL","HTFEC-L","TFEC-L"],"name":"transcription factor EC","description":"This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]","ncbiEntrezGeneId":22797,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/22797","proteins":[{"symbol":"TFEC_HUMAN","href":"/api/1.0/protein/TFEC_HUMAN"}],"hgncRootFamilies":[{"name":"Basic helix-loop-helix proteins (BHLH)","href":"/api/1.0/gene_family/Basic+helix-loop-helix+proteins+%28BHLH%29"}]}