{"symbol":"THEM4","synonyms":["CTMP"],"name":"thioesterase superfamily member 4","description":"Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":117145,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/117145","proteins":[{"symbol":"THEM4_HUMAN","href":"/api/1.0/protein/THEM4_HUMAN"}],"hgncRootFamilies":[]}