{"symbol":"TIAM2","synonyms":["TIAM-2","STEF"],"name":"T-cell lymphoma invasion and metastasis 2","description":"This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":26230,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/26230","proteins":[{"symbol":"TIAM2_HUMAN","href":"/api/1.0/protein/TIAM2_HUMAN"}],"hgncRootFamilies":[{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"},{"name":"Rho guanine nucleotide exchange factors (ARHGEF)","href":"/api/1.0/gene_family/Rho+guanine+nucleotide+exchange+factors+%28ARHGEF%29"}]}