{"symbol":"TICAM1","synonyms":["PRVTIRB","MYD88-3","IIAE6","TICAM-1"],"name":"toll-like receptor adaptor molecule 1","description":"This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]","ncbiEntrezGeneId":148022,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/148022","proteins":[{"symbol":"TCAM1_HUMAN","href":"/api/1.0/protein/TCAM1_HUMAN"}],"hgncRootFamilies":[]}