{"symbol":"TLE1","synonyms":["ESG","GRG1"],"name":"transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)","description":"Enables DNA-binding transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of anoikis; negative regulation of signal transduction; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":7088,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7088","proteins":[{"symbol":"TLE1_HUMAN","href":"/api/1.0/protein/TLE1_HUMAN"}],"hgncRootFamilies":[{"name":"WD repeat domain containing (WDR)","href":"/api/1.0/gene_family/WD+repeat+domain+containing+%28WDR%29"}]}