{"symbol":"TLE6","synonyms":["PREMBL","GRG6"],"name":"transducin-like enhancer of split 6","description":"This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]","ncbiEntrezGeneId":79816,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/79816","proteins":[{"symbol":"TLE6_HUMAN","href":"/api/1.0/protein/TLE6_HUMAN"}],"hgncRootFamilies":[{"name":"WD repeat domain containing (WDR)","href":"/api/1.0/gene_family/WD+repeat+domain+containing+%28WDR%29"}]}