{"symbol":"TLR5","synonyms":["TIL3","SLEB1","MELIOS","SLE1"],"name":"toll-like receptor 5","description":"This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]","ncbiEntrezGeneId":7100,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7100","proteins":[{"symbol":"TLR5_HUMAN","href":"/api/1.0/protein/TLR5_HUMAN"}],"hgncRootFamilies":[]}