{"symbol":"TM2D1","synonyms":["BBP"],"name":"TM2 domain containing 1","description":"The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer\u0027s disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]","ncbiEntrezGeneId":83941,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/83941","proteins":[{"symbol":"TM2D1_HUMAN","href":"/api/1.0/protein/TM2D1_HUMAN"}],"hgncRootFamilies":[]}