{"symbol":"TMED10","synonyms":["S31I125","TMP21","p24d1","TMP-21-I","S31III125","P24(DELTA)"],"name":"transmembrane emp24-like trafficking protein 10 (yeast)","description":"This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex\u0027s gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer\u0027s disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10972,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10972","proteins":[{"symbol":"TMEDA_HUMAN","href":"/api/1.0/protein/TMEDA_HUMAN"}],"hgncRootFamilies":[]}