{"symbol":"TMEM123","synonyms":["PORIMIN","KCT3"],"name":"transmembrane protein 123","description":"This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":114908,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/114908","proteins":[{"symbol":"PORIM_HUMAN","href":"/api/1.0/protein/PORIM_HUMAN"}],"hgncRootFamilies":[]}