{"symbol":"TMEM173","synonyms":["HSTING","HMITA","MPYS","STING-beta","STING","ERIS","SAVI","MITA","NET23"],"name":"transmembrane protein 173","description":"This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]","ncbiEntrezGeneId":340061,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/340061","proteins":[{"symbol":"STING_HUMAN","href":"/api/1.0/protein/STING_HUMAN"}],"hgncRootFamilies":[]}