{"symbol":"TMX1","synonyms":["TMX","TXNDC1","PDIA11","TXNDC"],"name":"thioredoxin-related transmembrane protein 1","description":"This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017]","ncbiEntrezGeneId":81542,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/81542","proteins":[{"symbol":"TMX1_HUMAN","href":"/api/1.0/protein/TMX1_HUMAN"}],"hgncRootFamilies":[{"name":"Protein disulfide isomerases (PDI)","href":"/api/1.0/gene_family/Protein+disulfide+isomerases+%28PDI%29"}]}