{"symbol":"TMX4","synonyms":["PDIA14","TXNDC13","DJ971N18.2"],"name":"thioredoxin-related transmembrane protein 4","description":"This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and C-terminal ASP/GLU-rich calcium binding domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The encoded protein has been shown to have reductase activity in vitro. [provided by RefSeq, Jan 2017]","ncbiEntrezGeneId":56255,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/56255","proteins":[{"symbol":"TMX4_HUMAN","href":"/api/1.0/protein/TMX4_HUMAN"}],"hgncRootFamilies":[{"name":"Protein disulfide isomerases (PDI)","href":"/api/1.0/gene_family/Protein+disulfide+isomerases+%28PDI%29"}]}