{"symbol":"TNFAIP3","synonyms":["A20","OTUD7C","AISBL","TNFA1P2"],"name":"tumor necrosis factor, alpha-induced protein 3","description":"This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]","ncbiEntrezGeneId":7128,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7128","proteins":[{"symbol":"TNAP3_HUMAN","href":"/api/1.0/protein/TNAP3_HUMAN"}],"hgncRootFamilies":[{"name":"OTU domain containing (OTUD)","href":"/api/1.0/gene_family/OTU+domain+containing+%28OTUD%29"}]}