{"symbol":"TNFRSF10B","synonyms":["TRAILR2","TRICK2B","ZTNFR9","KILLER/DR5","DR5","KILLER","TRICKB","TRICK2A","TRAIL-R2","TRICK2","CD262"],"name":"tumor necrosis factor receptor superfamily, member 10b","description":"The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]","ncbiEntrezGeneId":8795,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8795","proteins":[{"symbol":"TR10B_HUMAN","href":"/api/1.0/protein/TR10B_HUMAN"}],"hgncRootFamilies":[{"name":"Tumor necrosis factor receptor superfamily (TNFRSF)","href":"/api/1.0/gene_family/Tumor+necrosis+factor+receptor+superfamily+%28TNFRSF%29"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}