{"symbol":"TNFRSF18","synonyms":["AITR","GITR-D","CD357","GITR"],"name":"tumor necrosis factor receptor superfamily, member 18","description":"This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]","ncbiEntrezGeneId":8784,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8784","proteins":[{"symbol":"TNR18_HUMAN","href":"/api/1.0/protein/TNR18_HUMAN"}],"hgncRootFamilies":[{"name":"Tumor necrosis factor receptor superfamily (TNFRSF)","href":"/api/1.0/gene_family/Tumor+necrosis+factor+receptor+superfamily+%28TNFRSF%29"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}