{"symbol":"TNFRSF21","synonyms":["DR6","BM-018","CD358"],"name":"tumor necrosis factor receptor superfamily, member 21","description":"This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]","ncbiEntrezGeneId":27242,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/27242","proteins":[{"symbol":"TNR21_HUMAN","href":"/api/1.0/protein/TNR21_HUMAN"}],"hgncRootFamilies":[{"name":"Tumor necrosis factor receptor superfamily (TNFRSF)","href":"/api/1.0/gene_family/Tumor+necrosis+factor+receptor+superfamily+%28TNFRSF%29"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}