{"symbol":"TNFRSF4","synonyms":["CD134","OX40","IMD16","TXGP1L","ACT35"],"name":"tumor necrosis factor receptor superfamily, member 4","description":"The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":7293,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7293","proteins":[{"symbol":"TNR4_HUMAN","href":"/api/1.0/protein/TNR4_HUMAN"}],"hgncRootFamilies":[{"name":"Tumor necrosis factor receptor superfamily (TNFRSF)","href":"/api/1.0/gene_family/Tumor+necrosis+factor+receptor+superfamily+%28TNFRSF%29"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}