{"symbol":"TNFRSF8","synonyms":["KI-1","CD30","D1S166E"],"name":"tumor necrosis factor receptor superfamily, member 8","description":"The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":943,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/943","proteins":[{"symbol":"TNR8_HUMAN","href":"/api/1.0/protein/TNR8_HUMAN"}],"hgncRootFamilies":[{"name":"Tumor necrosis factor receptor superfamily (TNFRSF)","href":"/api/1.0/gene_family/Tumor+necrosis+factor+receptor+superfamily+%28TNFRSF%29"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}