{"symbol":"TNFSF12","synonyms":["TNLG4A","TWEAK","APO3L","DR3LG"],"name":"tumor necrosis factor (ligand) superfamily, member 12","description":"The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]","ncbiEntrezGeneId":8742,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8742","proteins":[{"symbol":"TNF12_HUMAN","href":"/api/1.0/protein/TNF12_HUMAN"}],"hgncRootFamilies":[{"name":"Tumor necrosis factor (ligand) superfamily (TNFSF)","href":"/api/1.0/gene_family/Tumor+necrosis+factor+%28ligand%29+superfamily+%28TNFSF%29"}]}