{"symbol":"TNKS","synonyms":["TNKS1","PARP5A","PART5","TIN1","ARTD5","PARP-5A","TINF1"],"name":"tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase","description":"Enables NAD+-protein poly-ADP-ribosyltransferase activity; histone binding activity; and zinc ion binding activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of chromosome organization. Acts upstream of or within peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Located in several cellular components, including chromosome, telomeric region; mitotic spindle pole; and nucleus. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":8658,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8658","proteins":[{"symbol":"TNKS1_HUMAN","href":"/api/1.0/protein/TNKS1_HUMAN"}],"hgncRootFamilies":[{"name":"Ankyrin repeat domain containing (ANKRD)","href":"/api/1.0/gene_family/Ankyrin+repeat+domain+containing+%28ANKRD%29"},{"name":"Poly (ADP-ribose) polymerases (PARP)","href":"/api/1.0/gene_family/Poly+%28ADP-ribose%29+polymerases+%28PARP%29"},{"name":"Sterile alpha motif (SAM) domain containing (SAMD)","href":"/api/1.0/gene_family/Sterile+alpha+motif+%28SAM%29+domain+containing+%28SAMD%29"}]}