{"symbol":"TNKS2","synonyms":["PARP5C","PARP-5C","PARP5B","PART6","ARTD6","TANK2","PARP-5B","TNKL"],"name":"tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2","description":"Enables NAD+-protein poly-ADP-ribosyltransferase activity and enzyme binding activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of telomere maintenance. Located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":80351,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/80351","proteins":[{"symbol":"TNKS2_HUMAN","href":"/api/1.0/protein/TNKS2_HUMAN"}],"hgncRootFamilies":[{"name":"Poly (ADP-ribose) polymerases (PARP)","href":"/api/1.0/gene_family/Poly+%28ADP-ribose%29+polymerases+%28PARP%29"},{"name":"Sterile alpha motif (SAM) domain containing (SAMD)","href":"/api/1.0/gene_family/Sterile+alpha+motif+%28SAM%29+domain+containing+%28SAMD%29"},{"name":"Ankyrin repeat domain containing (ANKRD)","href":"/api/1.0/gene_family/Ankyrin+repeat+domain+containing+%28ANKRD%29"}]}