{"symbol":"TNS1","synonyms":["MXRA6","PPP1R155","MSTP127","MST122","MST091","MSTP122","MST127","MSTP091","TNS"],"name":"tensin 1","description":"The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]","ncbiEntrezGeneId":7145,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7145","proteins":[{"symbol":"TENS1_HUMAN","href":"/api/1.0/protein/TENS1_HUMAN"}],"hgncRootFamilies":[{"name":"C2 domain containing","href":"/api/1.0/gene_family/C2+domain+containing"},{"name":"SH2 domain containing","href":"/api/1.0/gene_family/SH2+domain+containing"},{"name":"Phosphatases","href":"/api/1.0/gene_family/Phosphatases"},{"name":"Protein phosphatase 1 regulatory subunits (PPP1R)","href":"/api/1.0/gene_family/Protein+phosphatase+1+regulatory+subunits+%28PPP1R%29"}]}