{"symbol":"TOP3A","synonyms":["MGRISCE2","PEOB5","TOP3","ZGRF7"],"name":"topoisomerase (DNA) III alpha","description":"This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]","ncbiEntrezGeneId":7156,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7156","proteins":[{"symbol":"TOP3A_HUMAN","href":"/api/1.0/protein/TOP3A_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}