{"symbol":"TP53BP1","synonyms":["53BP1","TDRD30","P202","P53BP1"],"name":"tumor protein p53 binding protein 1","description":"This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]","ncbiEntrezGeneId":7158,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7158","proteins":[{"symbol":"TP53B_HUMAN","href":"/api/1.0/protein/TP53B_HUMAN"}],"hgncRootFamilies":[]}