{"symbol":"TPCN2","synonyms":["TPC2","SHEP10"],"name":"two pore segment channel 2","description":"This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]","ncbiEntrezGeneId":219931,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/219931","proteins":[{"symbol":"TPC2_HUMAN","href":"/api/1.0/protein/TPC2_HUMAN"}],"hgncRootFamilies":[{"name":"Ion channels","href":"/api/1.0/gene_family/Ion+channels"}]}