{"symbol":"TRADD","synonyms":["HS.89862"],"name":"TNFRSF1A-associated via death domain","description":"The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8717,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8717","proteins":[{"symbol":"TRADD_HUMAN","href":"/api/1.0/protein/TRADD_HUMAN"}],"hgncRootFamilies":[]}