{"symbol":"TRIM2","synonyms":["CMT2R","RNF86"],"name":"tripartite motif containing 2","description":"The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]","ncbiEntrezGeneId":23321,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23321","proteins":[{"symbol":"TRIM2_HUMAN","href":"/api/1.0/protein/TRIM2_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"},{"name":"Tripartite motif-containing (TRIM)","href":"/api/1.0/gene_family/Tripartite+motif-containing+%28TRIM%29"}]}