{"symbol":"TRIM23","synonyms":["RNF46","ARD1","ARFD1"],"name":"tripartite motif containing 23","description":"The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":373,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/373","proteins":[{"symbol":"TRI23_HUMAN","href":"/api/1.0/protein/TRI23_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"},{"name":"Tripartite motif-containing (TRIM)","href":"/api/1.0/gene_family/Tripartite+motif-containing+%28TRIM%29"},{"name":"Ras small GTPases superfamily","href":"/api/1.0/gene_family/Ras+small+GTPases+superfamily"}]}