{"symbol":"TRIM24","synonyms":["TF1A","HTIF1","RNF82","TIF1A","TIF1ALPHA","PTC6","TIF1"],"name":"tripartite motif containing 24","description":"The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8805,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8805","proteins":[{"symbol":"TIF1A_HUMAN","href":"/api/1.0/protein/TIF1A_HUMAN"}],"hgncRootFamilies":[{"name":"Tripartite motif-containing (TRIM)","href":"/api/1.0/gene_family/Tripartite+motif-containing+%28TRIM%29"},{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}