{"symbol":"TRIM3","synonyms":["RNF97","BERP","HAC1","RNF22"],"name":"tripartite motif containing 3","description":"The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the \u0027RING-B-box-coiled-coil\u0027 (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10612,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10612","proteins":[{"symbol":"TRIM3_HUMAN","href":"/api/1.0/protein/TRIM3_HUMAN"}],"hgncRootFamilies":[{"name":"Tripartite motif-containing (TRIM)","href":"/api/1.0/gene_family/Tripartite+motif-containing+%28TRIM%29"},{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}