{"symbol":"TRIM45","synonyms":["RNF99"],"name":"tripartite motif containing 45","description":"Enables ubiquitin protein ligase activity. Involved in negative regulation of inflammatory response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K48-linked ubiquitination. Located in cytosol; intercellular bridge; and nucleoplasm. Is active in cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":80263,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/80263","proteins":[{"symbol":"TRI45_HUMAN","href":"/api/1.0/protein/TRI45_HUMAN"}],"hgncRootFamilies":[{"name":"Tripartite motif-containing (TRIM)","href":"/api/1.0/gene_family/Tripartite+motif-containing+%28TRIM%29"},{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}