{"symbol":"TRIM5","synonyms":["RNF88","TRIM5ALPHA"],"name":"tripartite motif containing 5","description":"The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]","ncbiEntrezGeneId":85363,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/85363","proteins":[{"symbol":"TRIM5_HUMAN","href":"/api/1.0/protein/TRIM5_HUMAN"}],"hgncRootFamilies":[{"name":"Tripartite motif-containing (TRIM)","href":"/api/1.0/gene_family/Tripartite+motif-containing+%28TRIM%29"},{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}