{"symbol":"TRIOBP","synonyms":["DFNB28","HRIHFB2122","TARA","TAP68","DJ37E16.4"],"name":"TRIO and F-actin binding protein","description":"This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]","ncbiEntrezGeneId":11078,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/11078","proteins":[{"symbol":"TARA_HUMAN","href":"/api/1.0/protein/TARA_HUMAN"}],"hgncRootFamilies":[{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"}]}