{"symbol":"TRIP4","synonyms":["HST17391","SMABF1","ZC2HC5","ASC1","MDCDC"],"name":"thyroid hormone receptor interactor 4","description":"This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016]","ncbiEntrezGeneId":9325,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9325","proteins":[{"symbol":"TRIP4_HUMAN","href":"/api/1.0/protein/TRIP4_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}