{"symbol":"TRPC6","synonyms":["TRP6","FSGS2"],"name":"transient receptor potential cation channel, subfamily C, member 6","description":"The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]","ncbiEntrezGeneId":7225,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7225","proteins":[{"symbol":"TRPC6_HUMAN","href":"/api/1.0/protein/TRPC6_HUMAN"}],"hgncRootFamilies":[{"name":"Ion channels","href":"/api/1.0/gene_family/Ion+channels"}]}