{"symbol":"TRRAP","synonyms":["PAF400","STAF40","PAF350/400","TR-AP"],"name":"transformation/transcription domain-associated protein","description":"This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]","ncbiEntrezGeneId":8295,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8295","proteins":[{"symbol":"TRRAP_HUMAN","href":"/api/1.0/protein/TRRAP_HUMAN"}],"hgncRootFamilies":[]}