{"symbol":"TSC22D1","synonyms":["TGFB1I4","PTG-2","TSC22"],"name":"TSC22 domain family, member 1","description":"This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]","ncbiEntrezGeneId":8848,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8848","proteins":[{"symbol":"T22D1_HUMAN","href":"/api/1.0/protein/T22D1_HUMAN"}],"hgncRootFamilies":[]}