{"symbol":"TSEN34","synonyms":["SEN34","SEN34L","PCH2C","LENG5"],"name":"TSEN34 tRNA splicing endonuclease subunit","description":"This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Oct 2009]","ncbiEntrezGeneId":79042,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/79042","proteins":[{"symbol":"SEN34_HUMAN","href":"/api/1.0/protein/SEN34_HUMAN"}],"hgncRootFamilies":[{"name":"tRNA-splicing endonuclease subunits (TSEN)","href":"/api/1.0/gene_family/tRNA-splicing+endonuclease+subunits+%28TSEN%29"}]}