{"symbol":"TSPAN6","synonyms":["TSPAN-6","TM4SF6","T245"],"name":"tetraspanin 6","description":"The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013]","ncbiEntrezGeneId":7105,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7105","proteins":[{"symbol":"TSN6_HUMAN","href":"/api/1.0/protein/TSN6_HUMAN"}],"hgncRootFamilies":[{"name":"Tetraspanins (TSPAN)","href":"/api/1.0/gene_family/Tetraspanins+%28TSPAN%29"}]}