{"symbol":"TTF1","synonyms":["TTF-I"],"name":"transcription termination factor, RNA polymerase I","description":"This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias \u0027TFF1\u0027 with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011]","ncbiEntrezGeneId":7270,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7270","proteins":[{"symbol":"TTF1_HUMAN","href":"/api/1.0/protein/TTF1_HUMAN"}],"hgncRootFamilies":[{"name":"SANT/Myb domain containing","href":"/api/1.0/gene_family/SANT%24slash%24Myb+domain+containing"}]}