{"symbol":"TUBGCP4","synonyms":["GRIP76","MCCRP3","76P","GCP-4","GCP4"],"name":"tubulin, gamma complex associated protein 4","description":"This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]","ncbiEntrezGeneId":27229,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/27229","proteins":[{"symbol":"GCP4_HUMAN","href":"/api/1.0/protein/GCP4_HUMAN"}],"hgncRootFamilies":[]}