{"symbol":"TULP3","synonyms":["TUBL3"],"name":"tubby like protein 3","description":"This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2009]","ncbiEntrezGeneId":7289,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7289","proteins":[{"symbol":"TULP3_HUMAN","href":"/api/1.0/protein/TULP3_HUMAN"}],"hgncRootFamilies":[{"name":"Intraflagellar transport proteins (IFT)","href":"/api/1.0/gene_family/Intraflagellar+transport+proteins+%28IFT%29"}]}