{"symbol":"TUSC3","synonyms":["MRT7","D8S1992","M33","N33","MagT2","MRT22","OST3A"],"name":"tumor suppressor candidate 3","description":"This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017]","ncbiEntrezGeneId":7991,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7991","proteins":[{"symbol":"TUSC3_HUMAN","href":"/api/1.0/protein/TUSC3_HUMAN"}],"hgncRootFamilies":[]}