{"symbol":"TYK2","synonyms":["IMD35","JTK1"],"name":"tyrosine kinase 2","description":"This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020]","ncbiEntrezGeneId":7297,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7297","proteins":[{"symbol":"TYK2_HUMAN","href":"/api/1.0/protein/TYK2_HUMAN"}],"hgncRootFamilies":[]}